Name: Farshad Babaeijandaghi
Birthplace: Tehran, Iran
Nationality: Iranian
Previous or Current Education: Doctor of Medicine: 2001-2009

Graduate student: 2013-current

Research Summary: Antigen presenting cells (APCs) are necessary for the pathogenesis of Multiple sclerosis (MS). Microglia, brain infiltrating blood­derived monocytes, and dendritic cells are the three main types of professional APCs that are believed to have a role in the development of MS. Although some studies suggested that upon encountering myelin antigens APCs mature and travel to lymph nodes where they present the antigens to naïve T cells, others postulate that antigen presentation occurs in the brain. Using a parabiosis-irradiation-separation experimental paradigm that enables the discrimination of blood­derived monocytes from CNS­resident microglia, I am working to elucidate the precise roles of these two distinct populations of innate immune cells in the development of experimental autoimmune encephalitis (EAE) which is a well studied mouse model of the MS. We generate animals sharing a common blood through anastomotic vascular junctions by surgery. This procedure is relatively non-invasive and provides an ideal method for tracking the fate of bone marrow precursor cells generated in one mouse as they enter the circulation and colonize the peripheral tissues of the parabiont under homeostatic conditions and in the absence of such confounding factors as lethal irradiation and transplantation or chemically-induced forced mobilization of the donor cells from the bone marrow. I am also investigating where antigen presentation happens during EAE and which of these cell types is primarily responsible for presenting antigens to effector T cells.

Personal Summary: I got my doctoral degree in Medicine from Tehran University of Medical Sciences, Tehran, Iran, in 2009. Then, I started my research career at Stem Cell Technology Research Center, Tehran, Iran as a postdoctoral fellow. I joined the Rossi lab in January 2013.

Selected Publications:

[1] N. Ahmadbeigi, M. Soleimani, F. Babaeijandaghi, Y. Mortazavi, Y. Gheisari, M. Vasei, K. Azadmanesh, S. Rostami, A. Shafiee, N.B. Nardi, The aggregate nature of human mesenchymal stromal cells in native bone marrow. Cytotherapy 14 (2012) 917-924.

[2] Z. Hallaji, F. Babaeijandaghi, M. Akbarzadeh, S.Z. Seyedi, M. Barzegari, P. Noormohammadpour, Z. Shahabi, A.H. Ehsani, A significant association exists between the severity of nail and skin involvement in psoriasis. Journal of the American Academy of Dermatology 66 (2012) e12-e13.

[3] H. Mortazavi, F. Babaeijandaghi, M. Akbarzadeh, N. Rezaei, A. Amirzargar, M. Daneshpazhooh, A. Jalali, Z. Hallaji, The influence of systemic therapy on the serum levels of IL‐6 and IL‐8 in pemphigus vulgaris. Journal of the European Academy of Dermatology and Venereology (2011).

[4] I. Shabani, V. Haddadi-Asl, M. Soleimani, E. Seyedjafari, F. Babaeijandaghi, N. Ahmadbeigi, Enhanced infiltration and biomineralization of stem cells on collagen-grafted three-dimensional nanofibers. Tissue Engineering Part A 17 (2011) 1209-1218.

[5] F. Babaeijandaghi, I. Shabani, E. Seyedjafari, Z.S. Naraghi, M. Vasei, V. Haddadi-Asl, K.K. Hesari, M. Soleimani, Accelerated epidermal regeneration and improved dermal reconstruction achieved by polyethersulfone nanofibers. Tissue Engineering Part A 16 (2010) 3527-3536.

[6] I. Shabani, V. Haddadi-Asl, E. Seyedjafari, F. Babaeijandaghi, M. Soleimani, Improved infiltration of stem cells on electrospun nanofibers. Biochemical and biophysical research communications 382 (2009) 129-133

Contact: fbabaeijandaghi@brc.ubc.ca