Research Summary: Bone is constantly remodeled through the action of osteoblasts and osteoclasts, which are derived from two distinct lineages. Osteoblasts and osteoclasts also play an important role in the regeneration of bone after an injury or in cases of degenerative bone disorders. While osteoclasts are descended from a hematopoietic lineage, osteoblasts are derived from mesenchymal stem cells. My goal is to understand the role of mesenchymal stem cells in the regeneration of bone to determine their potential as a therapeutic target. Specifically, as most work involving the differentiation of MSCs to osteocytes has been performed in vitro, I am interested in the migration and differentiation process of mesenchymal stem cells to an osteogenic (bone) lineage in vivo.
Christine completed her Honours Bachelor of Science at the University of Ottawa in Biomedical Sciences. It was while completing her honours project that she discovered her interest in stem cells and regenerative medicine which lead her to the Experimental Medicine program and Fabio Rossi’s lab here at UBC.